Pneumococcal LytA Autolysin, a Potent Therapeutic Agent in Experimental Peritonitis-Sepsis Caused by Highly β-Lactam-Resistant Streptococcus pneumoniae

The in vitro and in vivo antipneumococcal activities of the main pneumococcal autolysin (LytA) and Cpl-1, a lysozyme encoded by phage Cp-1, were studied. Intraperitoneal therapy with LytA or high-dose Cpl-1 remarkably reduced peritoneal bacterial counts (>5 log(10) CFU/ml) compared with those for...

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Bibliographische Detailangaben
Hauptverfasser: Rodríguez-Cerrato, Violeta, García, Pedro, Huelves, Lorena, García, Ernesto, del Prado, Gema, Gracia, Matilde, Ponte, Carmen, López, Rubens, Soriano, Francisco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043201/
https://ncbi.nlm.nih.gov/pubmed/17576844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00137-07
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