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Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium

Bacterial pathogens produce complex carbohydrate capsules to protect against bactericidal immune molecules. Paradoxically, the pneumococcal capsule sensitizes the bacterium to antimicrobial peptides found on epithelial surfaces. Here we show that upon interaction with antimicrobial peptides, encapsu...

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Publicat a:Nat Commun
Autors principals: Kietzman, Colin C., Gao, Geli, Mann, Beth, Myers, Lance, Tuomanen, Elaine I.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773454/
https://ncbi.nlm.nih.gov/pubmed/26924467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10859
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