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Synergistic Killing of Streptococcus pneumoniae with the Bacteriophage Lytic Enzyme Cpl-1 and Penicillin or Gentamicin Depends on the Level of Penicillin Resistance

A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicill...

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Main Authors: Djurkovic, Svetolik, Loeffler, Jutta M., Fischetti, Vincent A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC549239/
https://ncbi.nlm.nih.gov/pubmed/15728935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1225-1228.2005
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