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Phage Lytic Enzyme Cpl-1 as a Novel Antimicrobial for Pneumococcal Bacteremia

Streptococcus pneumoniae is becoming increasingly antibiotic resistant worldwide, and thus new antimicrobials are badly needed. We report the use of Cpl-1, the lytic enzyme of a pneumococcal bacteriophage, as an intravenous therapy for pneumococcal bacteremia in a mouse model. A 2,000-μg dose of Cpl...

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Detalhes bibliográficos
Main Authors: Loeffler, Jutta M., Djurkovic, Svetolik, Fischetti, Vincent A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC219578/
https://ncbi.nlm.nih.gov/pubmed/14573637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.11.6199-6204.2003
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