Therapeutic Effects of Bacteriophage Cpl-1 Lysin against Streptococcus pneumoniae Endocarditis in Rats

Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log(10) CFU/g) within 2 h. Rapid bacterial lys...

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Main Authors: Entenza, J. M., Loeffler, J. M., Grandgirard, D., Fischetti, V. A., Moreillon, P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280127/
https://ncbi.nlm.nih.gov/pubmed/16251333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4789-4792.2005
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