Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analogues as potent EPAC antagonists

Two series of novel EPAC antagonists are designed, synthesized and evaluated in an effort to develop diversified analogues based on the scaffold of the previously identified high-throughput (HTS) hit 1 (ESI-09). Further SAR studies reveal that the isoxazole ring A of 1 can tolerate chemical modifica...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Ye, Na, Zhu, Yingmin, Liu, Zhiqing, Mei, Fang C., Chen, Haiying, Wang, Pingyuan, Cheng, Xiaodong, Zhou, Jia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492227/
https://ncbi.nlm.nih.gov/pubmed/28399451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.04.001
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