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Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analogues as potent EPAC antagonists

Two series of novel EPAC antagonists are designed, synthesized and evaluated in an effort to develop diversified analogues based on the scaffold of the previously identified high-throughput (HTS) hit 1 (ESI-09). Further SAR studies reveal that the isoxazole ring A of 1 can tolerate chemical modifica...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Ye, Na, Zhu, Yingmin, Liu, Zhiqing, Mei, Fang C., Chen, Haiying, Wang, Pingyuan, Cheng, Xiaodong, Zhou, Jia
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492227/
https://ncbi.nlm.nih.gov/pubmed/28399451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.04.001
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