Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway mediators that play important roles in cancer, diabetes, heart failure, inflammations, infections, neurological disorders and other human diseases. EPAC specific modulators are urgently needed to explo...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Liu, Zhiqing, Zhu, Yingmin, Chen, Haiying, Wang, Pingyuan, Mei, Fang C., Ye, Na, Cheng, Xiaodong, Zhou, Jia
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693616/
https://ncbi.nlm.nih.gov/pubmed/29100797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.10.056
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires