Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway mediators that play important roles in cancer, diabetes, heart failure, inflammations, infections, neurological disorders and other human diseases. EPAC specific modulators are urgently needed to explo...

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發表在:Bioorg Med Chem Lett
Main Authors: Liu, Zhiqing, Zhu, Yingmin, Chen, Haiying, Wang, Pingyuan, Mei, Fang C., Ye, Na, Cheng, Xiaodong, Zhou, Jia
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693616/
https://ncbi.nlm.nih.gov/pubmed/29100797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.10.056
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