Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

The bile acid-activated receptors, nuclear farnesoid X receptor (FXR) and the membrane Takeda G-protein receptor 5 (TGR5), are known to improve glucose and insulin sensitivity in obese and diabetic mice. However, the metabolic roles of these two receptors and the underlying mechanisms are incomplete...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Pathak, Preeti, Liu, Hailiang, Boehme, Shannon, Xie, Cen, Krausz, Kristopher W., Gonzalez, Frank, Chiang, John Y. L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Lipids
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491788/
https://ncbi.nlm.nih.gov/pubmed/28478385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784322
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