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Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

Bile acids activate farnesoid X receptor (FXR) and G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5) to regulate bile acid metabolism and glucose and insulin sensitivity. FXR and TGR5 are co-expressed in the enteroendocrine L cells but their roles in integrated regulation of metabolism are...

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Dettagli Bibliografici
Pubblicato in:Hepatology
Autori principali: Pathak, Preeti, Xie, Cen, Nichols, Robert G., Ferrell, Jessica M., Boehme, Shannon, Krausz, Kristopher W., Patterson, Andrew D., Gonzalez, Frank J., Chiang, John Y. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111007/
https://ncbi.nlm.nih.gov/pubmed/29486523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29857
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