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No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice

Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of a number of these enzymes with overlapping su...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Rolseth, Veslemøy, Luna, Luisa, Olsen, Ann Karin, Suganthan, Rajikala, Scheffler, Katja, Neurauter, Christine G., Esbensen, Ying, Kuśnierczyk, Anna, Hildrestrand, Gunn A., Graupner, Anne, Andersen, Jill M., Slupphaug, Geir, Klungland, Arne, Nilsen, Hilde, Bjørås, Magnar
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491499/
https://ncbi.nlm.nih.gov/pubmed/28663564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04472-4
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