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Identification of Inhibitors of the Association of ZAP-70 with the T-Cell Receptor by High-Throughput Screen
ZAP-70 is a critical molecule in the transduction of T-cell antigen receptor signaling and the activation of T cells. Upon activation of the T-cell antigen receptor, ZAP-70 is recruited to the intracellular ζ chains of the T-cell receptor, where ZAP-70 is activated and colocalized with its substrate...
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| Gepubliceerd in: | SLAS Discov |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5491343/ https://ncbi.nlm.nih.gov/pubmed/27932698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116681407 |
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