Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design

Establishing stable Chinese Hamster Ovary (CHO) cells producing monoclonal antibodies (mAbs) usually pass through the random integration of vectors to the cell genome, which is sensitive to gene silencing. One approach to overcome this issue is to target a highly transcribed region in the genome. Tr...

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Udgivet i:PLoS One
Main Authors: Ahmadi, Samira, Davami, Fatemeh, Davoudi, Noushin, Nematpour, Fatemeh, Ahmadi, Maryam, Ebadat, Saeedeh, Azadmanesh, Kayhan, Barkhordari, Farzaneh, Mahboudi, Fereidoun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491063/
https://ncbi.nlm.nih.gov/pubmed/28662065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179902
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