Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells

BACKGROUND: As the demand for monoclonal antibodies (mAb) increases, more efficient expression methods are required for their manufacturing process. Transcriptional gene silencing is a common phenomenon in recombinant cell lines which leads to expression reduction and instability. There are reports...

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Vydáno v:BMC Biotechnol
Hlavní autoři: Nematpour, Fatemeh, Mahboudi, Fereidoun, Vaziri, Behrouz, Khalaj, Vahid, Ahmadi, Samira, Ahmadi, Maryam, Ebadat, Saedeh, Davami, Fatemeh
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322649/
https://ncbi.nlm.nih.gov/pubmed/28228095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-017-0330-0
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