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Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer

Hyperactivation of the phosphatydil-inositol-3' phosphate kinase (PI3K)/AKT pathway is observed in most NSCLCs, promoting proliferation, migration, invasion and resistance to therapy. AKT can be activated through several mechanisms that include loss of the negative regulator PTEN, activating mu...

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הוצא לאור ב:	PLoS One
Main Authors:	De Marco, Carmela, Laudanna, Carmelo, Rinaldo, Nicola, Oliveira, Duarte Mendes, Ravo, Maria, Weisz, Alessandro, Ceccarelli, Michele, Caira, Elvira, Rizzuto, Antonia, Zoppoli, Pietro, Malanga, Donatella, Viglietto, Giuseppe
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science 2017
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5491004/ https://ncbi.nlm.nih.gov/pubmed/28662101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178865
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Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer

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