Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer

Hyperactivation of the phosphatydil-inositol-3' phosphate kinase (PI3K)/AKT pathway is observed in most NSCLCs, promoting proliferation, migration, invasion and resistance to therapy. AKT can be activated through several mechanisms that include loss of the negative regulator PTEN, activating mu...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: De Marco, Carmela, Laudanna, Carmelo, Rinaldo, Nicola, Oliveira, Duarte Mendes, Ravo, Maria, Weisz, Alessandro, Ceccarelli, Michele, Caira, Elvira, Rizzuto, Antonia, Zoppoli, Pietro, Malanga, Donatella, Viglietto, Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491004/
https://ncbi.nlm.nih.gov/pubmed/28662101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178865
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