A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens

Preferentially expressed antigen in melanoma (PRAME) is a cancer-testis antigen that is expressed in many cancers and leukemias. In healthy tissue, PRAME expression is limited to the testes and ovaries, making it a highly attractive cancer target. PRAME is an intracellular protein that cannot curren...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Chang, Aaron Y., Dao, Tao, Gejman, Ron S., Jarvis, Casey A., Scott, Andrew, Dubrovsky, Leonid, Mathias, Melissa D., Korontsvit, Tatyana, Zakhaleva, Victoriya, Curcio, Michael, Hendrickson, Ronald C., Liu, Cheng, Scheinberg, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490756/
https://ncbi.nlm.nih.gov/pubmed/28628042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92335
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