A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens

Preferentially expressed antigen in melanoma (PRAME) is a cancer-testis antigen that is expressed in many cancers and leukemias. In healthy tissue, PRAME expression is limited to the testes and ovaries, making it a highly attractive cancer target. PRAME is an intracellular protein that cannot curren...

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Vydáno v:J Clin Invest
Hlavní autoři: Chang, Aaron Y., Dao, Tao, Gejman, Ron S., Jarvis, Casey A., Scott, Andrew, Dubrovsky, Leonid, Mathias, Melissa D., Korontsvit, Tatyana, Zakhaleva, Victoriya, Curcio, Michael, Hendrickson, Ronald C., Liu, Cheng, Scheinberg, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490756/
https://ncbi.nlm.nih.gov/pubmed/28628042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92335
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