A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens

Preferentially expressed antigen in melanoma (PRAME) is a cancer-testis antigen that is expressed in many cancers and leukemias. In healthy tissue, PRAME expression is limited to the testes and ovaries, making it a highly attractive cancer target. PRAME is an intracellular protein that cannot curren...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Chang, Aaron Y., Dao, Tao, Gejman, Ron S., Jarvis, Casey A., Scott, Andrew, Dubrovsky, Leonid, Mathias, Melissa D., Korontsvit, Tatyana, Zakhaleva, Victoriya, Curcio, Michael, Hendrickson, Ronald C., Liu, Cheng, Scheinberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490756/
https://ncbi.nlm.nih.gov/pubmed/28628042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92335
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