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Symmetry and frustration in protein energy landscapes: A near degeneracy resolves the Rop dimer-folding mystery

Protein folding has become one of the best understood biochemical reactions from a kinetic viewpoint. The funneled energy landscape, a consequence of the minimal frustration achieved by evolution in sequences, explains how most proteins fold efficiently and robustly to their functional structure and...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Levy, Yaakov, Cho, Samuel S., Shen, Tongye, Onuchic, José N., Wolynes, Peter G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548997/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15701699/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409572102
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