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Mutations as trapdoors to two competing native conformations of the Rop-dimer
Conformational transitions play a central role in regulating protein function. Structure-based models with multiple basins have been used to understand the mechanisms governing these transitions. A model able to accommodate multiple folding basins is proposed to explore the mutational effects in the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2077020/ https://ncbi.nlm.nih.gov/pubmed/17968016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706077104 |
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