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Mutations as trapdoors to two competing native conformations of the Rop-dimer

Conformational transitions play a central role in regulating protein function. Structure-based models with multiple basins have been used to understand the mechanisms governing these transitions. A model able to accommodate multiple folding basins is proposed to explore the mutational effects in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schug, Alexander, Whitford, Paul C., Levy, Yaakov, Onuchic, José N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077020/
https://ncbi.nlm.nih.gov/pubmed/17968016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706077104
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