Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO(2)-induced ischemia and that LA...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hennebelle, Marie, Zhang, Zhichao, Metherel, Adam H., Kitson, Alex P., Otoki, Yurika, Richardson, Christine E., Yang, Jun, Lee, Kin Sing Stephen, Hammock, Bruce D., Zhang, Liang, Bazinet, Richard P., Taha, Ameer Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489485/
https://ncbi.nlm.nih.gov/pubmed/28659576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02914-7
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