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Linoleic acid-derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron-glia co-cultures in a sex-dependent manner

In adult rats, omega-6 linoleic acid (LA, 18:2n-6) serves as a precursor to oxidized LA metabolites (OXLAMs) known to regulate multiple signaling processes in the brain. However, little is known regarding the levels or role(s) of LA and its metabolites during brain development. To address this gap,...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Hennebelle, Marie, Morgan, Rhianna K., Sethi, Sunjay, Zhang, Zhichao, Chen, Hao, Grodzki, Ana Cristina, Lein, Pamela J., Taha, Ameer Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949423/
https://ncbi.nlm.nih.gov/pubmed/31283837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14818
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