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A Tunable Brake for HECT Ubiquitin Ligases
The HECT E3 ligases ubiquitinate numerous transcription factors and signaling molecules and their activity must be tightly controlled to prevent cancer, immune disorders, and other diseases. In this study we have found unexpectedly that peptide linkers tethering WW domains in several HECT family mem...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5489419/ https://ncbi.nlm.nih.gov/pubmed/28475870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.020 |
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