A Tunable Brake for HECT Ubiquitin Ligases

The HECT E3 ligases ubiquitinate numerous transcription factors and signaling molecules and their activity must be tightly controlled to prevent cancer, immune disorders, and other diseases. In this study we have found unexpectedly that peptide linkers tethering WW domains in several HECT family mem...

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Publicat a:Mol Cell
Autors principals: Chen, Zan, Jiang, Hanjie, Xu, Wei, Li, Xiaoguang, Dempsey, Daniel R., Zhang, Xiangbin, Devreotes, Peter, Wolberger, Cynthia, Amzel, Mario, Gabelli, Sandra, Cole, Philip A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489419/
https://ncbi.nlm.nih.gov/pubmed/28475870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.020
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