Targeting Notch-activated M1 Macrophages Attenuates Joint Tissue Damage in A Mouse Model of Inflammatory Arthritis

Expression of Notch signaling molecules are increased in synovium from patients with rheumatoid arthritis (RA). However, it is not known which cell type(s) in RA synovium have Notch activation or if they play a pathogenetic role in RA. Here, we used Hes1-GFP/TNF-transgenic (TNF-Tg) mice to investiga...

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Vydáno v:J Bone Miner Res
Hlavní autoři: Sun, Wen, Zhang, Hengwei, Wang, Hua, Chiu, Yahui Grace, Ritchlin, Christopher T., Kiernan, Amy, Boyce, Brendan F., Xing, Lianping
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489377/
https://ncbi.nlm.nih.gov/pubmed/28256007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3117
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