Targeting Notch-activated M1 Macrophages Attenuates Joint Tissue Damage in A Mouse Model of Inflammatory Arthritis

Expression of Notch signaling molecules are increased in synovium from patients with rheumatoid arthritis (RA). However, it is not known which cell type(s) in RA synovium have Notch activation or if they play a pathogenetic role in RA. Here, we used Hes1-GFP/TNF-transgenic (TNF-Tg) mice to investiga...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Sun, Wen, Zhang, Hengwei, Wang, Hua, Chiu, Yahui Grace, Ritchlin, Christopher T., Kiernan, Amy, Boyce, Brendan F., Xing, Lianping
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489377/
https://ncbi.nlm.nih.gov/pubmed/28256007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3117
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