Targeting Notch-activated M1 Macrophages Attenuates Joint Tissue Damage in A Mouse Model of Inflammatory Arthritis

Expression of Notch signaling molecules are increased in synovium from patients with rheumatoid arthritis (RA). However, it is not known which cell type(s) in RA synovium have Notch activation or if they play a pathogenetic role in RA. Here, we used Hes1-GFP/TNF-transgenic (TNF-Tg) mice to investiga...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Bone Miner Res
Egile Nagusiak: Sun, Wen, Zhang, Hengwei, Wang, Hua, Chiu, Yahui Grace, Ritchlin, Christopher T., Kiernan, Amy, Boyce, Brendan F., Xing, Lianping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489377/
https://ncbi.nlm.nih.gov/pubmed/28256007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3117
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