Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC

ACDC (arterial calcification due to deficiency of CD73) is an autosomal recessive disease resulting from loss-of-function mutations in NT5E, which encodes CD73, a 5′-ectonucleotidase that converts extracellular adenosine monophosphate to adenosine. ACDC patients display progressive calcification of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Jin, Hui, Hilaire, Cynthia St., Huang, Yuting, Yang, Dan, Dmitrieva, Natalia I., Negro, Alejandra, Schwartzbeck, Robin, Liu, Yangtengyu, Yu, Zhen, Walts, Avram, Davaine, Jean-Michel, Lee, Duck-Yeon, Donahue, Danielle, Hsu, Kevin S., Chen, Jessica, Cheng, Tao, Gahl, William, Chen, Guibin, Boehm, Manfred
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489239/
https://ncbi.nlm.nih.gov/pubmed/27965423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf9109
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados