Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC

ACDC (arterial calcification due to deficiency of CD73) is an autosomal recessive disease resulting from loss-of-function mutations in NT5E, which encodes CD73, a 5′-ectonucleotidase that converts extracellular adenosine monophosphate to adenosine. ACDC patients display progressive calcification of...

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Publicat a:Sci Signal
Autors principals: Jin, Hui, Hilaire, Cynthia St., Huang, Yuting, Yang, Dan, Dmitrieva, Natalia I., Negro, Alejandra, Schwartzbeck, Robin, Liu, Yangtengyu, Yu, Zhen, Walts, Avram, Davaine, Jean-Michel, Lee, Duck-Yeon, Donahue, Danielle, Hsu, Kevin S., Chen, Jessica, Cheng, Tao, Gahl, William, Chen, Guibin, Boehm, Manfred
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489239/
https://ncbi.nlm.nih.gov/pubmed/27965423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf9109
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