Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC

ACDC (arterial calcification due to deficiency of CD73) is an autosomal recessive disease resulting from loss-of-function mutations in NT5E, which encodes CD73, a 5′-ectonucleotidase that converts extracellular adenosine monophosphate to adenosine. ACDC patients display progressive calcification of...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Signal
मुख्य लेखकों: Jin, Hui, Hilaire, Cynthia St., Huang, Yuting, Yang, Dan, Dmitrieva, Natalia I., Negro, Alejandra, Schwartzbeck, Robin, Liu, Yangtengyu, Yu, Zhen, Walts, Avram, Davaine, Jean-Michel, Lee, Duck-Yeon, Donahue, Danielle, Hsu, Kevin S., Chen, Jessica, Cheng, Tao, Gahl, William, Chen, Guibin, Boehm, Manfred
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489239/
https://ncbi.nlm.nih.gov/pubmed/27965423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf9109
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