STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations

Human induced pluripotent stem cell (iPSC) technology has opened exciting opportunities for stem-cell-based therapy. However, its wide adoption is precluded by several challenges including low reprogramming efficiency and potential for malignant transformation. Better understanding of the molecular...

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Foilsithe in:Biol Open
Main Authors: Yu, Zhen, Dmitrieva, Natalia I., Walts, Avram D., Jin, Hui, Liu, Yangtengyu, Ping, Xianfeng, Ferrante, Elisa A., Qiu, Lugui, Holland, Steven M., Freeman, Alexandra F., Chen, Guibin, Boehm, Manfred
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists Ltd 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502598/
https://ncbi.nlm.nih.gov/pubmed/32580970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.052662
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