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Histamine modulation of the basal ganglia circuitry in the development of pathological grooming

Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Hdc knockout mice exhibit repetitive behavioral pathology and neuroch...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Rapanelli, Maximiliano, Frick, Luciana, Bito, Haruhiko, Pittenger, Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488951/
https://ncbi.nlm.nih.gov/pubmed/28584117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704547114
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