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Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

The aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is a defining characteristic of Alzheimer’s disease. Because of the complexity of this aggregation process, effective therapeutic inhibitors will need to target the specific microscopic steps that lead to the production of neurotoxic...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Munke, Anna, Persson, Jonas, Weiffert, Tanja, De Genst, Erwin, Meisl, Georg, Arosio, Paolo, Carnerup, Anna, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J., Linse, Sara
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488933/
https://ncbi.nlm.nih.gov/pubmed/28584111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700407114
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