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Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
The aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is a defining characteristic of Alzheimer’s disease. Because of the complexity of this aggregation process, effective therapeutic inhibitors will need to target the specific microscopic steps that lead to the production of neurotoxic...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5488933/ https://ncbi.nlm.nih.gov/pubmed/28584111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700407114 |
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