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Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants

Enzymes that can catalyze the macrocyclization of linear peptide substrates have long been sought for the production of libraries of structurally diverse scaffolds via combinatorial gene assembly as well as to afford rapid in vivo screening methods. Orbitides are plant ribosomally synthesized and po...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Chekan, Jonathan R., Estrada, Paola, Covello, Patrick S., Nair, Satish K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488928/
https://ncbi.nlm.nih.gov/pubmed/28584123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620499114
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