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Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants

Enzymes that can catalyze the macrocyclization of linear peptide substrates have long been sought for the production of libraries of structurally diverse scaffolds via combinatorial gene assembly as well as to afford rapid in vivo screening methods. Orbitides are plant ribosomally synthesized and po...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Chekan, Jonathan R., Estrada, Paola, Covello, Patrick S., Nair, Satish K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488928/
https://ncbi.nlm.nih.gov/pubmed/28584123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620499114
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