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Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis

Enzymes that generate ribosomally synthesized and posttranslationally modified peptide (RiPP) natural products have garnered significant interest, given their ability to produce large libraries of chemically diverse scaffolds. Such RiPP biosynthetic enzymes are predicted to bind their corresponding...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Chekan, Jonathan R., Ongpipattanakul, Chayanid, Nair, Satish K.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883790/
https://ncbi.nlm.nih.gov/pubmed/31719203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908364116
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