Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice – Implications for Superficial Erosion

RATIONALE: Superficial erosion currently causes up to a third of acute coronary syndromes (ACS), yet we lack understanding of its mechanisms. Thrombi due to superficial intimal erosion characteristically complicate matrix-rich atheromata in regions of flow perturbation. OBJECTIVE: This study tested...

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Udgivet i:Circ Res
Main Authors: Franck, Grégory, Mawson, Thomas, Sausen, Grasiele, Salinas, Manuel, Masson, Gustavo Santos, Cole, Andrew, Beltrami-Moreira, Marina, Chatzizisis, Yiannis, Quillard, Thibault, Tesmenitsky, Yevgenia, Shvartz, Eugenia, Sukhova, Galina K., Swirski, Filip K., Nahrendorf, Matthias, Aikawa, Elena, Croce, Kevin J., Libby, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488735/
https://ncbi.nlm.nih.gov/pubmed/28428204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.310694
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