GOT1-Mediated Anaplerotic Glutamine Metabolism Regulates Chronic Acidosis Stress In Pancreatic Cancer Cells

The increased rate of glycolysis and reduced oxidative metabolism are the principal biochemical phenotypes observed in pancreatic ductal adenocarcinoma (PDAC) that lead to the development of an acidic tumor microenvironment. The pH of most epithelial cell-derived tumors is reported to be lower than...

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Pubblicato in:Cancer Lett
Autori principali: Abrego, Jaime, Gunda, Venugopal, Vernucci, Enza, Shukla, Surendra K., King, Ryan J., Dasgupta, Aneesha, Goode, Gennifer, Murthy, Divya, Yu, Fang, Singh, Pankaj K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488721/
https://ncbi.nlm.nih.gov/pubmed/28455244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.04.029
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