GOT1-Mediated Anaplerotic Glutamine Metabolism Regulates Chronic Acidosis Stress In Pancreatic Cancer Cells

The increased rate of glycolysis and reduced oxidative metabolism are the principal biochemical phenotypes observed in pancreatic ductal adenocarcinoma (PDAC) that lead to the development of an acidic tumor microenvironment. The pH of most epithelial cell-derived tumors is reported to be lower than...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Abrego, Jaime, Gunda, Venugopal, Vernucci, Enza, Shukla, Surendra K., King, Ryan J., Dasgupta, Aneesha, Goode, Gennifer, Murthy, Divya, Yu, Fang, Singh, Pankaj K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488721/
https://ncbi.nlm.nih.gov/pubmed/28455244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.04.029
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