Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

BACKGROUND: The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS: Surface immunocytoc...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Lee, Paul R., Johnson, Tory P., Gnanapavan, Sharmilee, Giovannoni, Gavin, Wang, Tongguang, Steiner, Joseph P., Medynets, Marie, Vaal, Mark J., Gartner, Valerie, Nath, Avindra
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488439/
https://ncbi.nlm.nih.gov/pubmed/28655310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0901-y
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