Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent neurotoxicity. Here, we studied the mechanism...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wang, Tongguang, Lee, Myoung-Hwa, Choi, Elliot, Pardo-Villamizar, Carlos A., Lee, Sung Bin, Yang, In Hong, Calabresi, Peter A., Nath, Avindra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430617/
https://ncbi.nlm.nih.gov/pubmed/22952817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043950
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados