Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

BACKGROUND: The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS: Surface immunocytoc...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Lee, Paul R., Johnson, Tory P., Gnanapavan, Sharmilee, Giovannoni, Gavin, Wang, Tongguang, Steiner, Joseph P., Medynets, Marie, Vaal, Mark J., Gartner, Valerie, Nath, Avindra
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488439/
https://ncbi.nlm.nih.gov/pubmed/28655310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0901-y
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