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Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context‐Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space
Catalytic promiscuity can facilitate evolution of enzyme functions—a multifunctional catalyst may act as a springboard for efficient functional adaptation. We test the effect of single mutations on multiple activities in two groups of promiscuous AP superfamily members to probe this hypothesis. We q...
में बचाया:
| में प्रकाशित: | Chembiochem |
|---|---|
| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
John Wiley and Sons Inc.
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5488252/ https://ncbi.nlm.nih.gov/pubmed/28464395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600657 |
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