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Probing the mechanisms for the selectivity and promiscuity of methyl parathion hydrolase

Diverse organophosphate hydrolases have convergently evolved the ability to hydrolyse man-made organophosphates. Thus, these enzymes are attractive model systems for studying the factors shaping enzyme functional evolution. Methyl parathion hydrolase (MPH) is an enzyme from the metallo-β-lactamase s...

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Pubblicato in:Philos Trans A Math Phys Eng Sci
Autori principali: Purg, Miha, Pabis, Anna, Baier, Florian, Tokuriki, Nobuhiko, Jackson, Colin, Kamerlin, Shina Caroline Lynn
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052733/
https://ncbi.nlm.nih.gov/pubmed/27698033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsta.2016.0150
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