Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product‐like macrocyclic scaffolds of varied (12–20‐membered)...

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Bibliographische Detailangaben
Veröffentlicht in:Chemistry
Hauptverfasser: Dow, Mark, Marchetti, Francesco, Abrahams, Katherine A., Vaz, Luis, Besra, Gurdyal S., Warriner, Stuart, Nelson, Adam
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488202/
https://ncbi.nlm.nih.gov/pubmed/28374952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201701150
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