Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities

[Image: see text] In this study, we report the design and synthesis of a series of novel thiophene-arylamide compounds derived from the noncovalent decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) inhibitor TCA1 through a structure-based scaffold hopping strategy. Systematic optimization of the...

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Foilsithe in:J Med Chem
Main Authors: Wang, Pengxu, Batt, Sarah M., Wang, Bin, Fu, Lei, Qin, Rongfei, Lu, Yu, Li, Gang, Besra, Gurdyal S., Huang, Haihong
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2021
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154581/
https://ncbi.nlm.nih.gov/pubmed/33852302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00263
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