Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

Resistance against currently used antitubercular therapeutics increasingly undermines efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) inhibitors have shown nanomolar potency against both drug-susceptible and multidrug-resistant strains of the tubercle bac...

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Bibliografiset tiedot
Päätekijät: Batt, Sarah M., Jabeen, Talat, Bhowruth, Veemal, Quill, Lee, Lund, Peter A., Eggeling, Lothar, Alderwick, Luke J., Fütterer, Klaus, Besra, Gurdyal S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2012
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396498/
https://ncbi.nlm.nih.gov/pubmed/22733761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205735109
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