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Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
Resistance against currently used antitubercular therapeutics increasingly undermines efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) inhibitors have shown nanomolar potency against both drug-susceptible and multidrug-resistant strains of the tubercle bac...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396498/ https://ncbi.nlm.nih.gov/pubmed/22733761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205735109 |
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