Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

Resistance against currently used antitubercular therapeutics increasingly undermines efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) inhibitors have shown nanomolar potency against both drug-susceptible and multidrug-resistant strains of the tubercle bac...

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Hlavní autoři: Batt, Sarah M., Jabeen, Talat, Bhowruth, Veemal, Quill, Lee, Lund, Peter A., Eggeling, Lothar, Alderwick, Luke J., Fütterer, Klaus, Besra, Gurdyal S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396498/
https://ncbi.nlm.nih.gov/pubmed/22733761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205735109
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