Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

Resistance against currently used antitubercular therapeutics increasingly undermines efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) inhibitors have shown nanomolar potency against both drug-susceptible and multidrug-resistant strains of the tubercle bac...

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Bibliografiska uppgifter
Huvudupphovsmän: Batt, Sarah M., Jabeen, Talat, Bhowruth, Veemal, Quill, Lee, Lund, Peter A., Eggeling, Lothar, Alderwick, Luke J., Fütterer, Klaus, Besra, Gurdyal S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396498/
https://ncbi.nlm.nih.gov/pubmed/22733761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205735109
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