Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity

[Image: see text] We report a novel benzimidazole (BI) based DprE1 inhibitor that resulted from scaffold morphing of a 1,4-azaindole series. The clinical progression of the 1,4-azaindole series from our previous work validates the potential of exploring newer chemical entities with antimycobacterial...

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Pubblicato in:ACS Med Chem Lett
Autori principali: R, Manjunatha M., Shandil, Radha, Panda, Manoranjan, Sadler, Claire, Ambady, Anisha, Panduga, Vijender, Kumar, Naveen, Mahadevaswamy, Jyothi, Sreenivasaiah, M., Narayan, Ashwini, Guptha, Supreeth, Sharma, Sreevalli, Sambandamurthy, Vasan K., Ramachandran, Vasanthi, Mallya, Meenakshi, Cooper, Christopher, Mdluli, Khisi, Butler, Scott, Tommasi, Ruben, Iyer, Pravin S., Narayanan, Shridhar, Chatterji, Monalisa, Shirude, Pravin S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792157/
https://ncbi.nlm.nih.gov/pubmed/31620237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00343
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